A Chemical Examination of Himalyan Aconitum Species, A Cooperative Project at the University of Georgia, Award inU.S. and Indian Currencies

喜马拉雅乌头物种的化学检验，佐治亚大学合作项目，美国获奖

• 批准号: 8905629
• 负责人: S. Pelletier
• 金额: $ 1.24万
• 依托单位: University of Georgia Research Foundation Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-08-15 至 1992-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8905629&HistoricalAwards=false
• 关键词: Chemical; Examination; Himalyan; Aconitum; Species

Description: This project supports participation of an Indian scientist, Dr. K.S. Khetwal of the Department of Chemistry, Kumaon University, Nainital, India, in a project managed by Dr. S. Pelletier at the University of Georgia, Athens, GA. The research objective is to investigate the alkaloid constituents of certain Himalayan alkaloid-bearing species, including Aconitum balfourii Stapf (Ranunculaceae), A. laeve Royle, and A. violaceum Jacq. The extracts of these species will be screened for their biological activities. The funds will enable Dr. Khetwal to travel to Athens and work with Dr. Pelletier for approximately four months on the structural determination of active compounds using modern instrumentation including infrared, GC-MS spectra, proton and carbon-13 NMR spectroscopy. Techniques such as specific homonuclear- heteronuclear decoupling, off-resonance techniques, broad band decoupling, NOE, relaxation experiments and 2D-methods will be utilized to provide further insight into the complex structures. Scope: The project is expected to increase understanding of the chemistry of Indian plants, especially those from the Himalayan region, to select pharmacologically interesting compounds that merit careful study, and to better understand the relationship between the chemical structure and the bioactivity. The work will enhance the capability of the Indian scientist for carrying out useful Indo-U.S. collaboration when he returns to India.

说明：本项目支持一个 印度科学家K.S.博士外交部 印度奈尼塔尔Kumaon大学化学项目 由S博士管理。佩尔蒂埃在格鲁吉亚大学， 佐治亚州雅典 本研究的目的是探讨 某些喜马拉雅产生物碱成分 种，包括毛茛科（Ranunculaceae）的香蒲（Balfourii Stapf）， A. laeve Royle和A.紫花地丁 提取物 将对这些物种进行生物学筛选， 活动 这笔资金将使Khetwal博士能够前往 雅典和佩尔蒂埃博士一起工作大约四个月 活性化合物结构测定 使用现代仪器，包括红外线，GC-MS 光谱、质子和碳-13 NMR光谱。 技术 例如特定的同质-异质解耦， 非共振技术，宽带去耦，NOE， 松弛实验和二维方法将被用来 提供了对复杂结构的进一步了解。 范围：该项目预计将增加对 印度植物的化学成分，尤其是来自 喜马拉雅地区，选择有趣的 这些化合物值得仔细研究，为了更好地理解 化学结构与 生物活性 这项工作将提高 印度科学家进行了有益的印美。 当他回到印度时，