PERIMENOPAUSAL DEPRESSION AND GENETIC EXPRESSION OF ESTROGEN RECEPTOR ALPHA (ER-ALPHA), ESTROGEN RECEPTOR BETA (ER-BETA), SEROTONIN RECEPTOR 1A (5HT1A), AND TRYPTOPHAN HYDROXYLASE-1 (TPH-1) GENES

围绝经期抑郁和雌激素受体α (ER-α)、雌激素受体β (ER-β)、血清素受体1A (5HT1A) 和色氨酸羟化酶-1 (TPH-1) 基因的基因表达

• 批准号: 182334
• 负责人: Tramontina Juliana F
• 金额: $ 3.28万
• 依托单位: St. Joseph's Hospital (Hamilton, Ontario)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-02-01 至 2011-02-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=182334&lang=en
• 关键词: Estrogen; Gene Expression; Hormone; Menopause; Mood; Serotonin; Stressful Life Events

There is a body of evidence that demonstrated the presence of an increased vulnerability to depressive disorder during the perimenopausal period in some women (relative risk= 1.8-2.2). Estrogen is a potent neuromodulator and is known to alter the activiti

有大量证据表明，在围绝经期，一些妇女抑郁障碍的易感性增加（相对风险= 1.8-2.2）。雌激素是一种有效的神经调节剂，