Alpha1-Adrenergic Receptor Subtypes in SmoothMuscle

SmoothMuscle 中的 Alpha1 肾上腺素受体亚型

• 批准号: 8908074
• 负责人: Kenneth Minneman
• 金额: $ 25.85万
• 依托单位: Emory University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-11-15 至 1992-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8908074&HistoricalAwards=false
• 关键词: Alpha1; Adrenergic; Receptor; Subtypes; SmoothMuscle

This is a project to examine some of the processes by which blood pressure is regulated. Normally, the brain sends messages to arteries and veins through nerves. Activation of these nerves causes the blood vessels to contract by releasing a chemical messenger, norepinephrine. The receptor molecules for norepinephrine which are on the surface of the muscle cells in the blood vessels will be studied. Dr. Minneman has previously shown that there are several different types of such receptors, which are affected differently by various drugs. He will now study the molecular mechanisms by which these different receptor types cause the blood vessels to contract. He is particularly interested in whether these receptors are acting through different mechanisms to cause contraction, as is suggested by preliminary results. Identification of these different mechanisms will be important in understanding more about how blood pressure is regulated, and in helping to identify ways to selectively control blood pressure. //

这是一个项目，以检查一些过程， 压力得到调节。 正常情况下，大脑会向 通过神经的动脉和静脉。 激活这些神经 通过释放一种化学物质使血管收缩 信使去甲肾上腺素 受体分子 肌肉细胞表面的去甲肾上腺素 将研究血管。 Minneman博士此前曾 表明有几种不同类型的受体， 不同的药物会对它们产生不同的影响 他现在将 研究这些不同受体的分子机制 导致血管收缩。 他特别 感兴趣的是这些受体是否通过 引起收缩的不同机制，正如 初步结果。 识别这些不同的 机制将是重要的，在了解更多关于如何 血压得到调节，并帮助确定方法， 选择性地控制血压。//