Homogenous Antibody-Metal Conjugates For Immuno-Mass Spectrometry Imaging

用于免疫质谱成像的均质抗体-金属缀合物

• 批准号: DP230101740
• 负责人: A/Prof David Bishop
• 金额: $ 31.15万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230101740
• 关键词: Homogenous; Antibody; Metal; Conjugates; Immuno

This project aims to use bespoke metal labels and high-resolution mass spectrometry imaging to address current shortcomings in approaches that visualise and measure proteins in cells and tissue. It expects to substantially increase the utility of immuno-mass spectrometry imaging technology to analyses that are refractory to current techniques and workflows. Expected outcomes include metal probes that facilitate the spatial quantification of multiple biomolecules on a single histological section, providing significant benefits to bioscience laboratories that require complex workflows to visualise and obtain quantitative data on the expression of biomolecules.

该项目旨在使用定制的金属标签和高分辨率质谱成像来解决目前在可视化和测量细胞和组织中蛋白质的方法中存在的缺点。它预计将大大增加免疫质谱成像技术的实用性，以分析目前的技术和工作流程难以解决的问题。预期成果包括金属探针，有助于在单个组织学切片上对多个生物分子进行空间定量，为需要复杂工作流程来可视化和获得生物分子表达定量数据的生物科学实验室提供显着优势。