Studies in Molecular Recognition

分子识别研究

• 批准号: 8911008
• 负责人: W. Clark Still
• 金额: $ 57.96万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-06-15 至 1992-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8911008&HistoricalAwards=false
• 关键词: Studies; Molecular; Recognition

Still's research is supported by the Synthetic Organic Program. A professor of Chemistry at Columbia University, Still is studying how to prepare and computer-model structures and reactions of complex organic molecules. His work has already had impact on how chemists design and analyze molecular structure, and his studies continue to lead the way in this very important area. The objectives of this project are: 1) to prepare a series of conformationally restricted host molecules with three- dimensional binding sites, 2) to study their geometries and binding properties with guest molecules, and 3) to use the data obtained to test and evaluate a computational method for predicting binding properties.

斯蒂尔的研究得到了有机合成计划的支持。 作为哥伦比亚大学的化学教授，斯蒂尔正在研究如何制备复杂有机分子的结构和反应并对其进行计算机建模。 他的工作已经对化学家设计和分析分子结构的方式产生了影响，并且他的研究继续在这个非常重要的领域发挥引领作用。 该项目的目标是：1）制备一系列具有三维结合位点的构象限制的宿主分子，2）研究它们的几何形状和与客体分子的结合特性，3）使用获得的数据来测试和评估预测结合特性的计算方法。