Studies in Molecular Recognition

斯蒂尔的研究得到了合成有机项目的支持。作为哥伦比亚大学的化学教授，斯蒂尔正在研究如何制备和计算机模拟复杂有机分子的结构和反应。他的工作已经对化学家如何设计和分析分子结构产生了影响，他的研究继续引领着这个非常重要的领域。该项目的目标是：1)制备一系列具有三维结合位点的构象受限宿主分子；2)研究它们的几何形状和与客体分子的结合特性；3)使用获得的数据来测试和评估预测结合特性的计算方法。

Still's research is supported by the Synthetic Organic Program. A professor of Chemistry at Columbia University, Still is studying how to prepare and computer-model structures and reactions of complex organic molecules. His work has already had impact on how chemists design and analyze molecular structure, and his studies continue to lead the way in this very important area. The objectives of this project are: 1) to prepare a series of conformationally restricted host molecules with three- dimensional binding sites, 2) to study their geometries and binding properties with guest molecules, and 3) to use the data obtained to test and evaluate a computational method for predicting binding properties.