The Role of Insulin-like Growth Factors in Fetal Growth and Development

胰岛素样生长因子在胎儿生长发育中的作用

• 批准号: 8912246
• 负责人: James Wyche
• 金额: $ 6.5万
• 依托单位: Brown University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-08-01 至 1991-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8912246&HistoricalAwards=false
• 关键词: Role; Insulin; like; Growth; Factors

The objective of this research is to develop an in vivo system for study of the effects of maternal serum Insulin.like Growth Factor (IGF) levels on fetal rat development. The recognition that> growth factors may influence several aspects of development has excited interest in defining the true range of their effects and action mechanisms. IGF.II has been implicated as a regulator of embryogenis and fetal growth, and the proposed research seeks ultimately to determine the soundness of this implication. The experimental approach will utilize IGF.II secreting tumors to raise maternal IGF.II levels, and explore the relation of these elevated levels to placental.binding and passage of the factor, and to patterns of fetal growth. The initial objective is to determine the effectiveness of the tumor system for perturbing placental and fetal IGF.II levels. Subsequent efforts will be devoted to reducing the interpretive complexity of the system to a level that will permit direct analysis of IGF.II effects on the fetus. If successful, this system may generate data not easily available by other approaches, and increase our understanding of regulatory mechanisms of growth and development. //

本研究的目的是建立一个体内系统来研究母体血清胰岛素的作用。样生长因子（IGF）水平对胎鼠发育的影响认识到bb0生长因子可能影响发育的几个方面，人们对确定其作用和作用机制的真正范围产生了兴趣。IGF。II被认为是胚胎发生和胎儿生长的调节因子，提出的研究最终寻求确定这一含义的合理性。实验方法将利用IGF。II分泌肿瘤提高母体IGF。II水平，并探讨这些水平升高与胎盘的关系。因子的结合与传递，与胎儿生长模式有关。最初的目的是确定肿瘤系统干扰胎盘和胎儿IGF的有效性。二世的水平。随后的努力将致力于降低系统解释的复杂性，使其能够直接分析IGF。对胎儿的影响。如果成功，该系统可能产生其他方法难以获得的数据，并增加我们对生长和发育调节机制的理解。//