Cation Radical Explorations

这项来自有机动力学项目的资助将支持罗切斯特大学的Joseph P. Dinnocenzo博士的研究工作，他正在研究失去一个电子的分子的反应。对这些活性物质的研究将为酸碱反应提供基础信息，并为合成有机化学提供新的研究方法。丁诺森佐博士将要进行的实验将包括两个有关阳离子自由基的研究。第一个目的是提供叔胺阳离子自由基和烷基芳基阳离子自由基的动力学酸性的详细了解。可分离阳离子自由基盐的制备、表征和质子转移研究将提供动力学和热力学数据，这将有助于识别阳离子自由基去质子化与中性、闭壳有机分子去质子化的异同。第二项研究旨在阐明具有不饱和取代基的环丙烷阳离子自由基反应的范围、机理和合成应用。

This grant from the Organic Dynamics Program supports the continuing work of Dr. Joseph P. Dinnocenzo at the University of Rochester, who is studying the reactions of molecules from which a single electron has been removed. Investigations of these reactive species will provide fundamental information on acid-base reactions and should lead to new methodology in synthetic organic chemistry. The experiments to be carried out by Dr. Dinnocenzo will comprise two related investigations of cation radicals. The first is designed to provide a detailed understanding of the kinetic acidities of tertiary amine cation radicals and alkylaromatic cation radicals. Preparation, characterization, and proton-transfer studies of isolable cation radical salts will afford kinetic and thermodynamic data that will help to identify the similarities and differences between cation radical deprotonations and those of neutral, closed-shell organic molecules. The second investigation is designed to elucidate the scope, mechanism, and synthetic applications of cation radical reactions for cyclopropanes having unsaturated substituents.