Molecular Basis for the Potentiation and Subtype Specificity of Voltage Gated Potassium Channels

电压门控钾通道增强和亚型特异性的分子基础

• 批准号: 349939
• 负责人: Wang Caroline
• 金额: $ 1.27万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-12-01 至 2016-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=349939&lang=en
• 关键词: Epilepsy; Inteins; Kcnq2/3; Retigabine And Retigabine Analogues; Voltage Dependence

Epilepsy is the fourth most common neurological disorder and associated with multiple co-morbidities. Most current antiepileptic drugs target sodium channels or GABA signalling, but have significant drawbacks. Many epileptic patients experience side effec

癫痫是第四常见的神经系统疾病，与多种合并症有关。目前大多数抗癫痫药物靶向钠通道或GABA信号传导，但有显着的缺点。许多癫痫患者会出现副作用，