Sulfatase and aromatase pathways for estradiol synthesis in human breast cancer cells, tissues and animal models: identifying a combinatory therapy

人类乳腺癌细胞、组织和动物模型中雌二醇合成的硫酸酯酶和芳香酶途径：确定组合疗法

• 批准号: 180564
• 负责人: Lin Sheng-Xiang
• 金额: $ 56.31万
• 依托单位: Universit Laval
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-03-01 至 2014-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=180564&lang=en
• 关键词: A Combinatory Therapy For Breast Cancer; Animal Xenograft Models; Combined Use Of Enzyme Inhibitors; Enzyme Kinetics In Breast Cancer Cells; Enzymes Activating Estrogens; Sulfatase And Aromatase Pathways

It is now well-known that most breast tumours are sensitive to estrogens, that is, these steroid hormones contribute to their growth. Inhibiting the synthesis of these molecules within the body of cancer patients has thus been explored as a means of fight

现在众所周知，大多数乳腺肿瘤对雌激素敏感，也就是说，这些类固醇激素有助于它们的