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Sulfatase and aromatase pathways for estradiol synthesis in human breast cancer cells, tissues and animal models: identifying a combinatory therapy

Sulfatase and aromatase pathways for estradiol synthesis in human breast cancer cells, tissues and animal models: identifying a combinatory therapy
人类乳腺癌细胞、组织和动物模型中雌二醇合成的硫酸酯酶和芳香酶途径：确定组合疗法
批准号：
180564
负责人：
Lin Sheng-Xiang
金额：
$56.31万
依托单位：
Universit Laval
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2009
资助国家：
加拿大
项目状态：
已结题
起止时间：
2009-03-01 至 2014-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=180564&lang=en
关键词：
A Combinatory Therapy For Breast Cancer Animal Xenograft Models Combined Use Of Enzyme Inhibitors Enzyme Kinetics In Breast Cancer Cells Enzymes Activating Estrogens Sulfatase And Aromatase Pathways

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中文摘要
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英文摘要
It is now well-known that most breast tumours are sensitive to estrogens, that is, these steroid hormones contribute to their growth. Inhibiting the synthesis of these molecules within the body of cancer patients has thus been explored as a means of fight
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Pre-clinical pharmacokinetic and efficacy assays with an efficient 17beta-hydroxysteroid dehydrogenase type 7 inhibitor for breast cancer therapy
  • 批准号：
    494899
  • 项目类别：
    Operating Grants
  • 资助金额：
    $7.29万
  • 财政年份：
    2023
  • 负责人：
    Lin Sheng-Xiang
  • 依托单位：
    Universit Laval