New tools for real-time imaging of multiple signaling events in single cells: design, construction, and biological applications of genetically encoded biosensors

单细胞中多个信号事件实时成像的新工具：基因编码生物传感器的设计、构建和生物应用

• 批准号: 182523
• 负责人: Campbell Robert E
• 金额: $ 18.88万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-03-01 至 2012-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=182523&lang=en
• 关键词: Cancer And Diabetes; Dual Biosensors; Fluorescence Microscopy; Jellyfish And Coral Fluorescent Proteins; Organelle Signaling; Protein Engineering

Very few of the molecular tools employed in biomedical research have had greater impact than intrinsically fluorescent proteins from marine organisms. Indeed, the 2008 Nobel Prize in Chemistry was awarded to the pioneering researchers who discovered and d

生物医学研究中使用的分子工具很少有比海洋生物本身的荧光蛋白更有影响力的。事实上，2008年诺贝尔化学奖授予了那些发现并证明了