Molecular Biology of the hyperthermophile, methanogen AV19

超嗜热菌、产甲烷菌 AV19 的分子生物学

• 批准号: 9002729
• 负责人: John Reeve
• 金额: --
• 依托单位: Ohio State University Research Foundation -DO NOT USE
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-01-15 至 1991-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9002729&HistoricalAwards=false
• 关键词: Molecular; Biology; hyperthermophile; methanogen; AV19

Dr. Reeve has recently gained access, through a NATO sponsored collaboration with Professor K. O. Stetter in Germany, to an archaebacterium that is hyperthermophilic (grows only within the temperature range of 90 to 115 degrees Centigrade). These bacteria grow at the highest temperatures known for a living organism, and it is impossible to carry out genetic approaches to understanding how the bacterium can grow at these temperatures using current genetic techniques. Genes from the hyperthermophile AV19 will be cloned into Escherichia coli, where it may be possible to determine their function and DNA sequences. If preliminary experiments are successful under this Small Grant for Exploratory Research they will open up a major field of study that would be more appropriate for a larger award.

里夫博士最近与德国的k·o·斯泰特（K. O. Stetter）教授合作，在北约的赞助下，接触到了一种超嗜热的古细菌（只在90至115摄氏度的温度范围内生长）。这些细菌在生物体已知的最高温度下生长，使用现有的遗传技术不可能通过遗传方法来了解细菌如何在这些温度下生长。来自超嗜热细菌AV19的基因将被克隆到大肠杆菌中，在那里有可能确定它们的功能和DNA序列。如果初步实验在小额探索性研究资助下取得成功，他们将开辟一个更适合获得更大资助的主要研究领域。