Measuring G protein-coupled receptor signaling in vivo with resonance energy-based biosensors

使用基于共振能量的生物传感器测量体内 G 蛋白偶联受体信号传导

• 批准号: 365468
• 负责人: Jones-Tabah Jace
• 金额: $ 7.65万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-10-01 至 2019-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=365468&lang=en
• 关键词: Behavioral Pharmacology; Biased Agonism/Functional Selectivity; Cell Signalling; Dopamine Receptor Pharmacology; Fiber Photometry; G Protein-Coupled Receptors; In Vivo Imaging

G protein-coupled receptors (GPCRs) are proteins that modulate cellular function in response to being activated by hormones, neurotransmitters or drugs. The intracellular signal produced by a given GPCR is highly context dependent. Different physiological

G蛋白偶联受体（GPCR）是响应于被激素、神经递质或药物激活而调节细胞功能的蛋白质。由给定GPCR产生的细胞内信号是高度依赖于环境的。不同生理