Bifunctional non-secosteroidal vitamin D analogues as novel cancer therapeutics

双功能非甾体维生素 D 类似物作为新型癌症治疗药物

• 批准号: 358624
• 负责人: Gleason James L
• 金额: $ 29.26万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-10-01 至 2019-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=358624&lang=en
• 关键词: Cancer; Histone Deacetylases; Hybrid Molecules; Vitamin D; Xenograft Models

We have developed a novel class of molecules as potential cancer therapeutics that possess two distinct but complementary biochemical (or drug) activities within a single molecular backbone - essentially acting as two drugs in one. We previously found tha

我们开发了一类新型分子作为潜在的癌症治疗剂，它们在一个分子主链内具有两种不同但互补的生化（或药物）活性——本质上就像两种药物合二为一。我们之前发现