gp130 cytokines and IL-33 in progression to chronic lung fibrosis

gp130 细胞因子和 IL-33 进展为慢性肺纤维化

• 批准号: 357279
• 负责人: Richards Carl D
• 金额: $ 40.96万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-10-01 至 2020-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=357279&lang=en
• 关键词: Adenovirus Vectors; Animal Models Of Fibrosis; Fibroblasts And Epithelial Cells; Gene Targetted Mice; Gp130 Cytokines; Human-Derived Specimens; Influenza; Lung Fibrosis; Oncostatin M; Stat Cell Signalling

Buildup of scar tissue in chronic lung diseases such as idiopathic pulmonary fibrosis (IPF) results in local events in lungs that compromise lung function. These include the accumulation of inflammatory cells and decreases in oxygen exchange, and IPF pat

慢性肺部疾病（如特发性肺纤维化（IPF））中瘢痕组织的积聚导致肺部局部事件，损害肺功能。这些包括炎性细胞的积累和氧交换的减少，IPF患者