Investigating the role of amyloid beta, oxidative stress, and mitochondrial dysfunction in pre-symptomatic Alzheimer's disease

研究β淀粉样蛋白、氧化应激和线粒体功能障碍在阿尔茨海默病症状前的作用

• 批准号: 365464
• 负责人: Foret Morgan
• 金额: $ 7.65万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-10-01 至 2019-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=365464&lang=en
• 关键词: Alzheimer'S Disease; Early Amyloid Pathology; Ex-Vivo Imaging; Intracellular Amyloid Beta; Mitochondria Dysfunction; Novel Ros Detecting Fluorescent Probes; Pre-Clinical Stages; Primary Neuron Culture; Reactive Oxygen Species (Ros); Transgenic Rat Model

There are currently no cures nor preventative therapeutics for Alzheimer's disease (AD) which is the leading cause of dementia in the elderly. Clinical symptoms of AD including memory loss, appear late in the disease progression. Therefore, it is critical

阿尔茨海默病（AD）是老年人痴呆的主要原因，目前还没有治愈或预防性治疗方法。AD的临床症状包括记忆丧失，在疾病进展的后期出现。因此，