Development of Hybridoma Research Laboratory

该提案请求美国国家科学基金会协助在德克萨斯大学圣安东尼奥分校（UTSA）建立一个多用户杂交瘤研究实验室。该实验室将：(1)通过提供目前无法获得的昂贵、最先进的设备，提高和加强生命科学学院的研究能力，以促进单克隆抗体（MAb）技术在正在进行和计划中的研究项目中的应用；(2)提高和加强少数民族本科生和研究生的研究经验，促进他们获得智力和身体技能，使他们在迅速成为科学界所需背景的生物学领域具有竞争力；(3)促进UTSA与其他具有大量少数民族生物科学招生的区域学术机构之间的研究互动。此外，增加的研究经验预计将有助于增加少数民族学生进入生物科学职业。最初，九名研究人员和他们的学生提议利用杂交瘤研究实验室，促进单抗技术在生理学、分子细胞生物学、遗传学、生物化学和神经生物学等领域的应用。这些研究项目每年将影响14名少数民族本科生和7名少数民族研究生

This proposal requests assistance from the National Science Foundation to establish a multiuser Hybridoma Research Laboratory at The University of Texas at San Antonio (UTSA). The laboratory will: (1) enhance and strengthen the research capabilities of life science faculty by providing expensive, state-of-the-art equipment, not presently available, to facilitate the application of monoclonal antibody (MAb) technology to ongoing and planned research programs; (2) enhance and strengthen research experiences for minority undergraduate and graduate students by facilitating the acquisition of intellectual and physical skills to become competitive in an area of biology which is rapidly achieving status as required background by the scientific community; and (3) foster research interactions between UTSA and other regional academic institutions with large minority enrollments in the biological sciences. Furthermore, the enhanced research experiences are expected to contribute to increased entry of minority students into careers in the biosciences. Initially nine investigators and their students propose to utilize the Hybridoma Research Laboratory to facilitate the application of MAb technology to ongoing research programs in physiology, molecular cell biology, genetics, biochemistry and neurobiology. These research programs will impact 14 undergraduate and 7 graduate minority students per year.//