RUI: Ion Channels in Hypoxia and Hypothermia

RUI：缺氧和低温中的离子通道

• 批准号: 9005911
• 负责人: John Cameron
• 金额: $ 7.99万
• 依托单位: Wellesley College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-07-01 至 1992-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9005911&HistoricalAwards=false
• 关键词: RUI; Ion; Channels; Hypoxia; Hypothermia

The objective of this project is to provide new information on the cellar mechanisms that explain the ability of many 'cold blooded' animals to tolerate conditions of low (or no) oxygen and low temperature. The ability of many vertebrate animals to withstand environmental conditions that are completely incompatible with human life has intrigued scientist and laymen for centuries. We now know that some fish, amphibians (i.e., frog larvae) and reptiles (turtles, for example) are capable of surviving days, weeks, or even months buried in the mud at the bottom of frozen ponds, even though there may be essentially no oxygen present at all. While some species remain in a state of hibernation, during which their metabolism virtually comes to a halt, many other animals remain fully active at body temperatures that would be quickly fatal to humans. The mechanisms by which these animals tolerate such extreme conditions are very poorly understood. The goal of this project, then, is to begin to understand the fundamental mechanisms by which animals that are in many ways similar to humans are able to function under conditions so foreign to our existence. The key to this understanding may be differences in the way that substances such as calcium and potassium are permitted to move through the walls of cells in crucial organs, such as the brain and heart. If so, it may ultimately be possible to identify drugs that would expand the resistance of humans to extreme environmental conditions.

本项目的目标是提供关于 解释了许多“冷血动物”的能力的地窖机制 动物耐受低（或无）氧和低 温度 许多脊椎动物抵抗环境的能力 与人类生活完全不相容的环境 几个世纪以来一直吸引着科学家和门外汉 我们现在知道， 鱼，两栖动物（即，青蛙幼虫）和爬行动物（海龟， 例如）能够存活数天，数周，甚至数月， 冰冻池塘底部的泥浆，即使可能有 基本上根本不存在氧气。 虽然有些物种仍处于 冬眠状态，在此期间它们的新陈代谢几乎达到 停止后，许多其他动物在体温下仍然充分活跃 对人类来说是致命的 这些机制 人们对动物能忍受如此极端的环境知之甚少。 因此，本项目的目标是开始了解 在许多方面与人类相似的动物 人类能够在如此陌生的条件下运作， 存在 这种理解的关键可能在于 像钙和钾这样的物质 穿过重要器官的细胞壁，比如大脑， 心 如果是这样的话，最终可能会发现药物， 会增强人类对极端环境的抵抗力 条件