Functional studies of a genetic mutation in the development of a Wiskott-Aldrich-like syndrome in paediatric patients

儿童患者 Wiskott-Aldrich 样综合征发生过程中基因突变的功能研究

• 批准号: 363787
• 负责人: Leung Gabriella
• 金额: $ 3.28万
• 依托单位: Hospital for Sick Children (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-11-01 至 2018-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=363787&lang=en
• 关键词: Actin Cytoskeleton; B Cells; Live Cell Imaging; Macrophages; Very Early Onset Inflammatory Bowel Disease (Veo-Ibd); Whole Exome Sequencing (Wes); Zebrafish

Canada has one of the highest rates of inflammatory bowel disease (IBD) in the world with 1 in 150 affected, the incidence of which is also increasing globally. The pathogenesis of IBD is the combination of many factors including the microbiota, immune sy

加拿大是世界上炎症性肠病（IBD）发病率最高的国家之一，每150人中就有1人受到影响，其发病率在全球范围内也在增加。IBD的发病机制是多种因素共同作用的结果，包括微生物群、免疫系统、免疫功能、免疫功能等。