IL-37 recruitment of SIGIRR: A novel mechanism to suppress intestinal epithelial cell driven inflammation and microbial dysbiosis in Inflammatory Bowel Disease.

SIGIRR 的 IL-37 募集：抑制炎症性肠病中肠上皮细胞驱动的炎症和微生物失调的新机制。

• 批准号: 363772
• 负责人: Allaire Joannie
• 金额: --
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-11-01 至 2018-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=363772&lang=en
• 关键词: Dysbiosis; Enteroids; Epithelial Cells; Ibd; Il37; Innate Immune Signaling; Microbiota; Pathobionts; Sigirr

Patients with Inflammatory Bowel Disease (IBD) suffer bouts of extreme gut inflammation that disrupt the population of bacteria in their intestines. Thus IBD patients often have fewer beneficial bacteria and suffer an overgrowth of potentially dangerous b

患有炎症性肠病（IBD）的患者遭受极端肠道炎症的发作，这些炎症破坏了肠道中的细菌种群。因此，IBD患者体内的有益菌通常较少，而潜在危险的B菌则过度生长