Development of the Lamprey Central Pattern Generator for Locomotion

用于运动的七鳃鳗中央模式发生器的开发

• 批准号: 9009570
• 负责人: Avis Cohen
• 金额: $ 20.3万
• 依托单位: University of Maryland, College Park
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-08-01 至 1994-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9009570&HistoricalAwards=false
• 关键词: Development; Lamprey; Central; Pattern; Generator

Movement by animals including man, requires precise timing to be smooth and coordinated. The neurons which control movement have been in existence for millions of years and if we can understand how they work we will have fundamental knowledge for understanding numerous aspects of movement from designing robots to rehabilitating stroke victims. The proposed study will focus on one of the oldest vertebrates known . the lamprey. Its nervous system has to provide accurate wave motions through pattern generating nerves which can be recorded in vitro. Also the lamprey undergoes a protracted larval phase during which the pace maker neurons must change cell firing rates to maintain the exact phase of the rhythm even though the neurons are growing longer and thereby taking longer to fire the muscle. The study will provide both basic biological data of the cell firing patterns during fictive swimming and also a mathematical analysis of the stable and unstable patterns and phase shifts. The work should tell us much about very basic events in the control of movement.

包括人类在内的动物的运动需要精确的时间 要平稳协调 控制运动的神经元 已经存在了数百万年，如果我们能 了解它们是如何工作的，我们将有基本的知识， 从设计机器人的角度来理解运动的许多方面 帮助中风患者康复 拟议的研究将侧重于 已知最古老的脊椎动物之一。七鳃鳗 其 神经系统必须提供精确的波动， 可以在体外记录的模式生成神经。 也 七鳃鳗经历了一个漫长的幼虫期， 起搏神经元必须改变细胞放电率，以维持 即使神经元在生长 从而需要更长的时间来激发肌肉。 研究 将提供细胞放电的基本生物学数据 在虚构的游泳模式，也是一个数学分析 稳定和不稳定的模式和相移。 工作 应该告诉我们很多关于控制的基本事件 运动