Mechanical regulation of gene expression associated with metastatic aggression in bone-seeking breast cancer cells.

与寻骨乳腺癌细胞转移侵袭相关的基因表达的机械调节。

• 批准号: 367260
• 负责人: Mei Junyi
• 金额: $ 1.27万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-12-01 至 2017-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=367260&lang=en
• 关键词: Bone; Bone Stroma; Breast Cancer; Fluid Flow Stimuli; Gene Expression; Mechanical Loading; Metastasis; Osteocyte; Perivascular Niche; Tumor Agression

Breast cancer relapses can occur decades after successful treatment. When relapses involve cancer cells that have traveled through the bloodstream to settle in bone, these new tumors, termed metastases, become incurable. Bone metastases are responsible fo

乳腺癌复发可能发生在成功治疗后几十年。当复发涉及癌细胞已经通过血流定居在骨骼中时，这些新的肿瘤，称为转移，变得无法治愈。骨转移是导致