Solution structure and interactions of a triple negative breast cancer target

三阴性乳腺癌靶点的溶液结构和相互作用

• 批准号: 367259
• 负责人: McLennan Steffane D
• 金额: $ 1.27万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-12-01 至 2017-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=367259&lang=en
• 关键词: Allostery; Camk1d; Fragment Based Drug Discovery; Phosphorylation; Triple Negative Breast Cancer

Triple Negative Breast Cancer (TNBC) is a particularly aggressive breast cancer subtype which has no effective cure. Calmodulin Dependent Protein Kinase 1 Delta (CaMK1D), which is overexpressed in 80% of TNBC tumours, has been identified as a putative dri

三阴性乳腺癌(TNBC)是一种侵袭性特别强的乳腺癌亚型，目前尚无有效的治疗方法。钙调蛋白依赖蛋白激酶1Delta(CaMK1D)在80%的TNBC肿瘤中过表达，已被确定为可能的DRI。