Functional Interactions Between Neuronal 5-HT and Glial S-100 Beta

神经元 5-HT 和神经胶质 S-100 Beta 之间的功能相互作用

• 批准号: 9013332
• 负责人: Efrain Azmitia
• 金额: $ 1.35万
• 依托单位: New York University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-02-01 至 1992-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9013332&HistoricalAwards=false
• 关键词: Functional; Interactions; Between; Neuronal; HT

A central issue in developmental neurobiology is the role of cell-cell interactions in regulating neuronal differentiation. Astrocytes secrete factors that influence neuronal differentiation, including S-100 beta, a factor that affects serotonergic neurons. In turn, the secretion of S-100 beta from astrocytes is regulated by activation of serotonergic neurons. The mechanisms of these cellular interactions will be investigated at the molecular level by studying the transcription, translation and release of S-100 beta. In addition, the regulatory role of steroid hormones, specifically the glucocorticoids, in these processes will be studied. The PI will undertake these studies at Cold Spring Harbor during a one year Sabbatical leave where he will be trained in molecular and protein techniques in the laboratory of Dr. Daniel Marshak.

发育神经生物学的一个中心问题是细胞间相互作用在调节神经元分化中的作用。星形胶质细胞分泌影响神经元分化的因子，包括S-100β，一种影响5-羟色胺能神经元的因子。反过来，星形胶质细胞分泌S-100β受到5-羟色胺能神经元激活的调节。这些细胞相互作用的机制将通过研究S-100β的转录、翻译和释放从分子水平上进行研究。此外，还将研究类固醇激素，特别是糖皮质激素在这些过程中的调节作用。PI将在一年的休假期间在冷泉港进行这些研究，在那里他将在Daniel Marshak博士的实验室接受分子和蛋白质技术培训。