The Identification of the Amino Acids on Platelet Factor 4 That Bind Pathogenic Antibodies in Heparin-Induced Thrombocytopenia

肝素诱导的血小板减少症中血小板因子 4 上与致病性抗体结合的氨基酸的鉴定

• 批准号: 383339
• 负责人: Huynh Angela
• 金额: $ 7.65万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-10-01 至 2020-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=383339&lang=en
• 关键词: Antibody Epitope Mapping; Heparin-Induced Thrombocytopenia; Platelet Activation; Platelet Factor 4

At least 30% of patients admitted into the hospital will be exposed to the common anticoagulant, heparin. 1-3% of these patients develop heparin-induced thrombocytopenia (HIT): an adverse drug reaction that can lead to amputations, strokes, and death. HIT

至少30%的入院患者会接触到常见的抗凝剂肝素。这些患者中有1-3%发生肝素诱导的血小板减少症（HIT）：一种可导致截肢、中风和死亡的药物不良反应。击中