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The Identification of the Amino Acids on Platelet Factor 4 That Bind Pathogenic Antibodies in Heparin-Induced Thrombocytopenia

The Identification of the Amino Acids on Platelet Factor 4 That Bind Pathogenic Antibodies in Heparin-Induced Thrombocytopenia
肝素诱导的血小板减少症中血小板因子 4 上与致病性抗体结合的氨基酸的鉴定
批准号:
383339
负责人:
Huynh Angela
金额:
$7.65万
依托单位:
依托单位国家:
加拿大
项目类别:
Studentship Programs
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-10-01 至 2020-10-01

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中文摘要
翻译
至少30%的入院患者会接触到常见的抗凝血剂肝素。这些患者中有1-3%出现肝素诱导的血小板减少症(HIT):一种可导致截肢、中风和死亡的药物不良反应。打击
英文摘要
At least 30% of patients admitted into the hospital will be exposed to the common anticoagulant, heparin. 1-3% of these patients develop heparin-induced thrombocytopenia (HIT): an adverse drug reaction that can lead to amputations, strokes, and death. HIT
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会议论文
Pathogenic Antibodies in Heparin-induced Thrombocytopenia Specifically Target an Immunodominant Region on Platelet Factor 4
  • 批准号:
    411554
  • 项目类别:
  • 资助金额:
    $0.07万
  • 财政年份:
    2019
  • 负责人:
    Huynh Angela
  • 依托单位:
海外基金