Post-Translational Regulation of N-Cadherin During Neural Development

神经发育过程中 N-钙粘蛋白的翻译后调节

• 批准号: 9021703
• 负责人: Gerald Grunwald
• 金额: $ 11.87万
• 依托单位: Thomas Jefferson University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-15 至 1996-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9021703&HistoricalAwards=false
• 关键词: Post; Translational; Regulation; Cadherin; During

The role of epigenetic regulation of the calcium dependent cell adhesion molecule, N-cadherin, in cell adhesion will be studied in the chick neural retina. Biochemical studies will be performed to describe the post-translational modification of N- cadherin by phosphorylation and sulfation and the relationship of these post-translational modifications to N-cadherin function will be determined. More generally, these studies will define mechanisms involved in cell-cell interactions that are important to the development of neuronal specificity.

本文将研究表观遗传调控钙依赖性细胞粘附分子n -钙粘蛋白在鸡神经视网膜细胞粘附中的作用。将进行生化研究来描述N-钙粘蛋白通过磷酸化和磺化的翻译后修饰，并确定这些翻译后修饰与N-钙粘蛋白功能的关系。更一般地说，这些研究将定义细胞-细胞相互作用的机制，这对神经元特异性的发展很重要。