Structural Recognition in Complexation of Organic Compounds

将研究有机主客体之间的络合物的化学性质。这项研究将专注于将客人监禁在坚硬的中空宿主中，要么没有洞(石蜡)，要么壳上有洞(半碳)。对于分子量在80-120之间的脂肪族和芳香族客体，都将测量由半心包复合体收缩结合的自由能。复合化和去复合化的速度将与半脑复合体中客体和入口的相对大小相关。将比较在溶解的去角质复合体的内部相中运行的反应的速率和产物，以及在没有主体的相同溶剂中运行的反应的速率和产物。宾客将被设计、准备和研究，其中只有一部分可以被监禁，其余的太大了，无法通过东道主的大门。一条小分子绳索将把这两部分连接起来。其他客人将被研究，其中一部分将被包含在一个半心中，另一部分将被包含在第二个半心中。该产品将是由一条短分子绳连接的两个半脑神经丛。将设计和合成新的碳化物和半碳化物家族。有机合成计划正在为这项诺贝尔奖研究的更新提供资金。它将继续发展囚禁在大分子中的小分子的化学。这项工作有可能导致非常独特的新的反应性模式。

The chemical character of complexes between organic hosts and guests will be studied. The research will focus on the incarceration of guests in rigidly hollow hosts either without holes (carcerands) or with holes (hemicarcerands) in their shells. The free energies of constrictive binding by hemicarceplexes will be measured for both aliphatic and aromatic guests in the molecular weight range of about 80-120. The rates of complexation and decomplexation will be correlated with the relative sizes of the guests and portals in hemicarceplexes. Comparisons will be made between the rates and products of reactions run in the interior phases of dissolved demicarceplexes, and those run in the same solvents free of the hosts. Guests will be designed, prepared, and studied, only a part of which can be incarcerated, the rest being too large to pass through the portals of the hosts. A small molecular tether will connect the two parts. Other guests will be studied, one part of which will be contained in one hemicarcerand and a second part in a second hemicarcerand. The product will be two hemicarceplexes connected by a short molecular tether. New families of carcerands and hemicarcerands will be designed and synthesized. The Organic Synthesis Program is funding the renewal of this Nobel Prize research. It will continue its development of the chemistry of small molecules imprisoned inside larger molecules. The work has the potential to lead to very unique new patterns of reactivity.