Faculty Awards for Women

女性教师奖

• 批准号: 9024304
• 负责人: JoAnn Silverstein
• 金额: $ 25万
• 依托单位: University of Colorado at Boulder
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-11-01 至 1997-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9024304&HistoricalAwards=false
• 关键词: Faculty; Awards; Women

The researcher will investigate: 1) whether substrate enhancement occurs with other xenobiotic compounds, particularly other substituted phenols (chloro- and methyl-) which are among the more mobile hazardous contaminants; 2) the effect of a single supplemental substrate on degradation of a mixture of two or more xenobiotic compounds by bacterial consortia in cell recycle systems; 3) if large populations of degrading bacteria can be maintained in a biofilm growing on inert particles without added supplemental feed; 4) whether the activated sludge floc or biofilm morphology protects individual bacteria from toxicity effects of xenobiotic compounds. After the laboratory experiment, the nominee will carry out simulations at pilot- or demonstration-scale. These will allow the P.I. to investigate the effects of mixing, aeration and biomass separation, variables that are best studies in large scale, and to verify the predictive models on large biodegradation systems. One benefit of this research is that phenomena identified in pure bacterial cultures can be researched in mixed populations. Usually this application is made by engineers without research on the mechanism in mixed communities of microorganisms which develop in nonsterile field processes. A second benefit is the investigation of non-specific enhancement mechanisms, like the growth of floc particles to retain bacteria, so that a single biodegradation process can be used in many contaminant removal systems. Finally, some conditions which greatly affect biodegradation cannot be studied in bench-scale simulations. Doing research at a larger scale will help to avoid process failures which occur when scale-up effects are not understood.

研究者将调查：1）底物是否 其他异生素化合物，特别是 其它取代的酚类（氯-和甲基-）， 更多的移动的有害污染物; 2）单一的 补充基质对两种或更多种 细菌聚生体在细胞再循环中产生的异生物质化合物 3）如果大量的降解细菌可以被 保持在惰性颗粒上生长的生物膜中，而不添加 补充进料; 4）活性污泥絮凝物或生物膜 形态学保护单个细菌免受 异生物化合物 实验室实验结束后，被提名者将进行 在试点或示范规模的模拟。 这将使 P.I.研究了混合、曝气和生物量的影响， 分离，变量是大规模研究的最佳选择， 验证大型生物降解系统的预测模型。 这项研究的一个好处是， 可以在混合种群中研究纯细菌培养物。 通常这种应用程序是由工程师没有研究 微生物混合群落的机制 在非无菌现场过程中。 第二个好处是 非特异性增强机制的研究，如 絮凝物颗粒的增长，以保留细菌，使一个单一的 生物降解工艺可用于许多污染物的去除 系统. 最后，一些条件，极大地影响 生物降解不能在实验室规模的模拟中进行研究。 做 更大规模的研究将有助于避免过程失败 这发生在不了解放大效应时。