Tuning the activating stimulus of voltage-gated sodium channels

调节电压门控钠通道的激活刺激

• 批准号: DP230100728
• 负责人: Dr Angelo Keramidas
• 金额: $ 33.39万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-19 至 2026-01-18
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230100728
• 关键词: Tuning; activating; stimulus; voltage; gated

This proposal aims to advance fundamental knowledge about how proteins (ion channels) found on the surface of neurons (brain cells and nerves) function as molecular conduits of cell-to-cell electrical communication. We aim to study how molecular probes and structural parts of these proteins affect the local chemical environment of ion channels, and how this leads to fine tuning of the ion channel's sensitivity to the stimulus that activates them (cell membrane voltage). The conceptual knowledge gained from this project would advance our understanding of a fundamental physiological process and facilitate the development of drugs that regulate ion channel function, such as anti-epileptics, analgesics and insecticides.

该提案旨在推进关于神经元（脑细胞和神经）表面上发现的蛋白质（离子通道）如何作为细胞间电通信的分子管道的基础知识。我们的目标是研究这些蛋白质的分子探针和结构部分如何影响离子通道的局部化学环境，以及这如何导致离子通道对激活它们的刺激（细胞膜电压）的敏感性的微调。 从这个项目中获得的概念知识将促进我们对基本生理过程的理解，并促进调节离子通道功能的药物的开发，如抗癫痫药，镇痛药和杀虫剂。