Measuring Parkison’s Disease Mitochondrial Protein Turnover Rates in IPSC-Derived Organoids and Mouse SNc by Mass Spectrometry

通过质谱法测量 IPSC 衍生类器官和小鼠 SNc 中的帕金森病线粒体蛋白周转率

• 批准号: 386388
• 负责人: DUCHESNE Anthony J
• 金额: $ 1.27万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-12-01 至 2018-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=386388&lang=en
• 关键词: Hplc-Qtof; Ipsc Organoids; Lc-Ms/Ms; Liquid Chromatography; Mass Spectrometry; Mitochondrial Turnover; Parkin; Parkinson'S Disease; Pink1; Proteomics

Parkinson's Disease (PD) is a currently incurable prevalent neurodegenerative disorder that manifests primarily in the elderly through motor symptoms of bradykinesia, rigidity and tremor. The disease causes the death of dopaminergic neurons in motor areas

帕金森病(PD)是一种目前无法治愈的普遍神经退行性疾病，主要表现在老年人，表现为运动迟缓、僵硬和震颤。这种疾病导致运动区的多巴胺能神经元死亡。