Presidential Young Investigator/Development of Peptide Synthesis Methodology

这项研究由有机合成计划资助。 Peter T.兰斯伯里，谁被指定为总统 年轻的调查员，将为他提供支持， 研究了五年。 他将用这笔资金学习 酶机制、生物合成和蛋白质问题 结构 这项研究将围绕发展对 控制肽的分子相互作用的细节 折页. 这涉及到新型固相的发展 片段偶联方法来生产大量的 目的蛋白 这将允许构象研究 和特异性标记蛋白质的合成，以简化 傅里叶变换光谱分析和二维 核磁共振波谱学 这些技术将 可用于研究多糖蛋白质相互作用。

This research is being funded by the Organic Synthesis Program. Dr. Peter T. Lansbury, who is being designated a Presidential Young Investigator which will provide him support for his research for five years. He will use the funds to study problems of enzyme mechanism, biosynthesis and protein structure. The research will center around developing understanding of the details of the molecular interactions which govern peptide folding. This involves the development of novel solid-phase fragment coupling methodolgy to produce large quantities of the target protein. This will then permit conformational studies and the synthesis of specifically labeled protein to simplify analysis by Fourier-transform spectroscopy and two dimensional nuclear magnetic resonance spectroscopy. These techniques will be applied to study polysaccharide protein interactions.