Investigating mechanisms of in vivo variability in spindle assembly checkpoint strength

研究纺锤体组装检查点强度的体内变异机制

• 批准号: 381022
• 负责人: Gerhold Abigail
• 金额: $ 49.6万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-03-01 至 2023-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=381022&lang=en
• 关键词: Asymmetric Cell Division; C. Elegans Genetics; Cell Polarity; Germ Line; Live-Cell Imaging; Mitosis; Quantitative Image Analysis; Spindle Assembly Checkpoint; Stem Cells

Uncontrolled cell division forms the basis for all cancers. Consequently, most anti-cancer drugs block the cell cycle, with many specifically targeting mitosis (e.g. Taxol). Variable drug efficiency is a major obstacle in the development of robust cancer

不受控制的细胞分裂是所有癌症的基础。因此，大多数抗癌药物阻断细胞周期，其中许多特异性靶向有丝分裂（例如紫杉醇）。可变的药物效率是发展稳健癌症的主要障碍