Development of Microdomain RF Coils for NMR Microscopy

该项目的目标是开发新的微型 射频线圈，将扩大核磁共振的应用 显微镜的视野比以前更小 研究了 我们建议开发新的线圈直径小， 为10 μ m，这将是两个数量级小于 目前使用的那些。 在这些尺寸下，传统电路 用于表征线圈和 样本不足。 因此，我们建议进行一项 较完整的理论分析和实验验证， 线圈性能 该评估将包括1）设计和 新线圈配置的制造，2）电气 线圈参数（电阻，电感， 品质因数），以及3）线圈性能的验证（信号- 噪声比，图像分辨率）。 的结果 研究将是新的微域线圈，具有增强的灵敏度， 小的成像体积和改善的信噪比。

The goal of this project is the development of new miniature radio frequency coils that will extend the application of NMR microscopy to smaller fields of view than have previously been studied. We propose to develop new coils with diameters as small as 10 um, which would be two orders of magnitude smaller than those presently used. At these dimensions, traditional circuit models used to characterize the interaction between the coil and the sample are inadequate. Therefore, we propose to conduct a more complete theoretical analysis and experimental validation of coil performance. This evaluation will include 1) design and fabrication of new coil configurations, 2) electrical characterization of coil parameters (resistance, inductance, quality factor), and 3) verification of coil performance (signal- to-noise, image resolution) at 300 MHz. The results of this study will be new microdomain coils with enhanced sensitivity for small imaging volumes and improved signal-to-noise.