Do bias signaling of the apelinergic receptor can improve the treatment of acute cardiovascular dysfunction and injury related to septic shock?

肾上腺能受体的偏向信号传导是否可以改善急性心血管功能障碍和感染性休克相关损伤的治疗？

• 批准号: 396834
• 负责人: Coquerel David
• 金额: $ 6.56万
• 依托单位: Universit de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-11-01 至 2020-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=396834&lang=en
• 关键词: Acute Heart Failure; Apelin Receptor; Bias Signaling; Cardiomyocytes; Sepsis

Urgent stabilization of hemodynamics and organ/tissue perfusion is a cornerstone in septic shock treatment, which seriously affects the myocardial function and the vascular tree. Catecholamines treatment, in concert with fluid resuscitation, has long been

血流动力学和器官/组织灌注的紧急稳定是脓毒性休克治疗的基石，严重影响心肌功能和血管树。长期以来，与液体复苏相结合的儿茶酚胺治疗一直是