Combatting the burden of drug-related toxicities in childhood cancer through genomics-based interventions

通过基于基因组学的干预措施来应对儿童癌症中药物相关毒性的负担

• 批准号: 396835
• 负责人: Loucks Catrina M
• 金额: $ 9.83万
• 依托单位: BC Children's Hospital Research Institute
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-11-01 至 2021-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=396835&lang=en
• 关键词: Childhood Cancer; Drug-Related Toxicities; Methotrexate; Mucositis; Pharmacogenomics

While the 5-year survival rates for children with cancer continue to improve, the major problem of drug-related side effects remains. For example, the cancer therapy drug, methotrexate, can save a child's life, but it can also lead to mucositis, a painful

虽然癌症儿童的5年存活率继续提高，但与药物有关的副作用的主要问题仍然存在。例如，癌症治疗药物甲氨蝶呤可以挽救儿童的生命，但它也可能导致粘膜炎，一种痛苦的疾病。