Investigating the role of APJ heterodimers in pain modulation

研究 APJ 异二聚体在疼痛调节中的作用

• 批准号: 397425
• 负责人: Besserer-Offroy Elie
• 金额: $ 9.83万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-11-01 至 2021-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=397425&lang=en
• 关键词: Apelin; Biais Signaling; Cellular Signaling; G Protein-Coupled Receptor; Heterodimerization; Kappa-Opioid; Neurotensin; Pain; Signaling Complexes Formation

A large number of currently prescribed drugs target G-protein coupled receptors (GPCRs). These transmembrane proteins form the most important protein family present at the cell surface. GPCRs are involved in transducing a signal from the surrounding cellu

目前大量的处方药靶向G蛋白偶联受体（GPCR）。这些跨膜蛋白形成存在于细胞表面的最重要的蛋白质家族。GPCR参与从周围细胞转导信号，