Intravenous Coronary Angiography Utilizing K-Emission and Bremsstrahlung X-Rays Produced by Electron Bombardment

利用电子轰击产生的 K 发射和轫致辐射 X 射线进行静脉冠状动脉造影

• 批准号: 9108883
• 负责人: Herbert Zeman
• 金额: $ 14.3万
• 依托单位: The University of Tennessee, Memphis - The Health Science Center
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-15 至 1994-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9108883&HistoricalAwards=false
• 关键词: Intravenous; Coronary; Angiography; Utilizing; Emission

The current technique of coronary angiography requires the injection of a contrast agent into the coronary artery; this procedure is expensive and potentially hazardous theoretical analysis shows that by taking the difference between X-rays at two different energies, and by using an appropriate contrast agent and signal processing techniques, coronary angiograms can be obtained using intravenous injection. This proposal is to test the feasibility of the approach without the development of an X-ray tube that is able to handle the necessary high electron currents. The proposed approach is to generate images of phantoms using low electrode currents (form the Brookhaven Dynamitron electron accelerator) and using averaging to compensate for the low current. If the preliminary results are promising, and follow-up work is successful, a safer and lower cost angiographic technology will result.

目前的冠状动脉造影技术需要将造影剂注射到冠状动脉中；该过程昂贵且存在潜在危险。理论分析表明，通过获取两种不同能量的 X 射线之间的差异，并使用适当的造影剂和信号处理技术，可以使用静脉注射获得冠状动脉血管造影照片。 该提案旨在测试该方法的可行性，而无需开发能够处理必要高电子电流的 X 射线管。 所提出的方法是使用低电极电流（来自 Brookhaven Dynamitron 电子加速器）并使用平均来补偿低电流来生成模型图像。 如果初步结果有希望，并且后续工作取得成功，将会产生更安全、成本更低的血管造影技术。