Photodynamics of Metalloporphyrins

格林鲍姆博士建议研究环境特异性 一组合成金属卟啉的光动力学活性 用作血红素加氧酶抑制剂。 光的吸收 这些卟啉在有氧环境中的结果产生 单线态氧，这可能会导致不可逆的修改， 以生物分子为目标 光反应性 特定的化合物取决于中心金属原子、环 取代基，以及卟啉被取代的环境。 本地化。 通过使用各种生物化学和光谱 技术，静电相互作用的重要性 卟啉-卟啉、卟啉-蛋白质和卟啉-膜 卟啉介导的损伤的关联和特定机制 将研究这些模型系统中的各种目标。

Dr. Greenbaum proposes to study the environment-specific photodynamic activity of a group of synthetic metalloporphyrins used as heme oxygenase inhibitors. Absorption of light by some of these porphyrins in aerobic environments results in generation of singlet oxygen, which may cause irreversible modification of target biological molecules. The photoreacitivity of a particular compound depends upon the central metal atom, ring substituents, and the environment in which the porphyrin is localized. By use of various biochemical and spectroscopic techniques, the importance of electrostatic interactions in porphyrin-porphyrin, porphyrin-protein, and porphyrin-membrane associations and specific mechanisms of porphyrin-mediated damage to the various targets in these model systems will be studied.