Novel Platinum Thiazole Complexes

该项目包括噻唑衍生物铂配合物的合成和表征，以及它们与核酸及其成分结合的后续研究。这将是特伦顿州立学院本科生研究项目的一部分。计划用x射线晶体学对配合物进行详细的检查。额外的工作将包括详细分析它们的结合模式，以阐明与DNA相互作用的机制。研究计划补助金使以前没有获得独立的联邦研究支持的妇女能够制定具有竞争力的研究计划。该项目涉及铂类有机金属化合物的合成和表征及其与DNA的结合。

The project involves the synthesis and characterization of the platinum complexes of thiazole derivatives and subsequent studies of their binding to nucleic acids and their constituents. This will be part of an undergraduate research program at Trenton State College. A detailed examination of the complexes by x-ray crystallography is planned. Additional work will include a detailed analysis of their binding modes in order to elucidate the mechanism of interaction with DNA. %%% Research Planning Grants enable women who have not had prior independent Federal research support to develop a competitive research proposal. This project involves the synthesis and characterization of platinum organometallic compounds and their bonding to DNA.