Determining the predominant autophagic forms and genetic determinants of macrophage lipophagy

确定巨噬细胞脂肪吞噬的主要自噬形式和遗传决定因素

• 批准号: 406278
• 负责人: Fairman Garrett
• 金额: $ 1.27万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-12-01 至 2019-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=406278&lang=en
• 关键词: Lipid Droplet Autophagy; Lipophagy Selectivity; Macro-Autophagy And Micro-Autophagy; Macrophage Foam Cell; Yeast Genetic Screen

High fat diets lead to an increased risk of a disease known as atherosclerosis, which is a major cause of heart disease. Atherosclerosis is characterized by the accumulation of fat particles within specialized cells of the immune system known as macrophag

高脂肪饮食会增加患动脉粥样硬化的风险，这是心脏病的主要原因。动脉粥样硬化的特征是脂肪颗粒在免疫系统中称为巨噬细胞的特殊细胞内的积累