The Role of Lysosomal Acid Lipase in Atherosclerotic Lesion Smooth Muscle Cells

溶酶体酸性脂肪酶在动脉粥样硬化病变平滑肌细胞中的作用

• 批准号: 406411
• 负责人: Besler Katrina
• 金额: $ 1.27万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-12-01 至 2019-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=406411&lang=en
• 关键词: Atherosclerosis; Atp Binding Cassette Transporter A1; Cholesterol; Crispr Cas9; Foam Cells; Ldl; Lysosomal Acid Lipase; Macrophages; Mouse Model; Smooth Muscle Cells

BACKGROUND: Heart attack and stroke together are the leading cause of death in Canada and the world. They result from atherosclerosis, or hardening of the arteries, a disease in which cholesterol builds up in artery walls. This causes arteries to become i

背景：心脏病发作和中风一起是加拿大和世界的主要死亡原因。它们是由动脉粥样硬化或动脉硬化引起的，这是一种胆固醇在动脉壁中积聚的疾病。这会导致动脉变成I