Relative Radical Stabilization Energies

相对自由基稳定能

• 批准号: 9113323
• 负责人: Frederick Bordwell
• 金额: $ 27万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-07-01 至 1994-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9113323&HistoricalAwards=false
• 关键词: Relative; Radical; Stabilization; Energies

With support from the Organic Dynamics Program, Dr. Bordwell will develop new methods for estimating the magnitudes of bond dissociation energies (BDEs). These studies are expected to provide quantitative estimates of the relative magnitudes of BDEs and the corresponding radical stabilization energies (RSEs) for the species that are formed upon homolytic cleavage of bonds between hydrogen and other atoms. His work will provide the first quantitative estimates of the relative magnitudes of RSEs for a large number of radicals. At the same time, these measurements will serve to extend the dimethylsulfoxide-based acidity scale, which provides quantitative measures of anion basicities and, through the Bronsted equation, their reactivities toward electrophiles. %%% Knowledge of the energies, called "bond dissociation energies", that are required to cleave particular chemical bonds is important to physical-organic chemists who seek to develop fundamental structure-activity relationships that can be used to predict the reactivities of individual chemical bonds in a given molecule toward a particular reagent. This information, in turn, can be used by synthetic organic chemists in developing new synthetic strategies.

在有机动力学项目的支持下，博德维尔博士 将开发新的方法来估计债券的规模， 离解能（BDEs）。这些研究预计将 提供定量估计的相对幅度 BDEs和相应的自由基稳定化能 均裂后形成的物质的RSE 氢原子和其他原子之间的键。他的工作将 第一次定量估计相对 大量的自由基的RSE的大小。在同一 这些措施将有助于延长 二甲基亚砜为基础的酸度标度，它提供 阴离子碱度的定量测量，并通过 布朗斯台德方程，它们对亲电试剂的反应性。 %%% 关于能量的知识，叫做“键离解能”， 所需的化学键的化学反应， 对于那些寻求发展 基本的结构-活性关系， 预测单个化学键的反应性， 特定的反应物。这些信息， 反过来，可以被合成有机化学家用于 开发新的合成策略。