US-Hungary Joint Fund Neuro Science Research on Characteristics of External Ca2+ -Independent Transmitter Release

美匈联合基金神经科学研究外部Ca2+非依赖性递质释放特征

• 批准号: 9116137
• 负责人: Vera Adam-Vizi
• 金额: --
• 依托单位: Semmelweis University Medical School
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-06-01 至 1995-06-01
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9116137&HistoricalAwards=false
• 关键词: US; Hungary; Joint; Fund; Neuro

The primary objective of this US-Hungary cooperative research project between Dr. Vera Adam-Vizi of Semmelweiss University of Medicine, Budapest and Dr. Abel Lajtha of the N.S. Kline Institute, Orangeburg, NY is to examine the mechanism of which calcium is released when nerves release neurotransmitters, causing a concentration in extracellular fluids. The researchers intend to 1) differentiate between a non-specific increase in external calcium and one which is due to calcium released from nerve terminans; and 2) identify which fraction of the neurotransmitter stored in nerve terminals is susceptible to changes in external calcium concentration. Results may reveal molecular mechanisms which are associated with transmitter secretion. Funds for the project are awarded through the U.S.-Hungary Joint Fund, Budapest in accordance with established guidelines.

布达佩斯 Semmelweiss 医科大学的 Vera Adam-Vizi 博士和 N.S. 的 Abel Lajtha 博士之间的这个美国-匈牙利合作研究项目的主要目标是纽约州奥兰治堡克莱恩研究所将研究神经释放神经递质导致细胞外液浓缩时释放钙的机制。 研究人员打算：1）区分外部钙的非特异性增加和由于神经末梢释放的钙引起的钙增加； 2）确定存储在神经末梢的神经递质的哪一部分容易受到外部钙浓度变化的影响。 结果可能揭示与递质分泌相关的分子机制。 该项目的资金由布达佩斯的美国-匈牙利联合基金根据既定准则提供。