US-Hungary Joint Fund Neuro Science Research on Characteristics of External Ca2+ -Independent Transmitter Release

这项由布达佩斯Semmelweiss医学院的Vera Adam-Vizi博士和纽约州奥兰吉堡N.S. Kline研究所的Abel Lajtha博士合作开展的美国-匈牙利合作研究项目的主要目标是研究神经释放神经递质时钙释放的机制，引起细胞外液的浓度。研究人员打算1)区分外部钙的非特异性增加和由于神经末梢释放的钙的增加；2)确定储存在神经末梢的神经递质中哪一部分易受外界钙浓度变化的影响。结果可能揭示与递质分泌相关的分子机制。该项目的资金由设在布达佩斯的美国-匈牙利联合基金按照既定的指导方针发放。

The primary objective of this US-Hungary cooperative research project between Dr. Vera Adam-Vizi of Semmelweiss University of Medicine, Budapest and Dr. Abel Lajtha of the N.S. Kline Institute, Orangeburg, NY is to examine the mechanism of which calcium is released when nerves release neurotransmitters, causing a concentration in extracellular fluids. The researchers intend to 1) differentiate between a non-specific increase in external calcium and one which is due to calcium released from nerve terminans; and 2) identify which fraction of the neurotransmitter stored in nerve terminals is susceptible to changes in external calcium concentration. Results may reveal molecular mechanisms which are associated with transmitter secretion. Funds for the project are awarded through the U.S.-Hungary Joint Fund, Budapest in accordance with established guidelines.