Structural Studies of the Gamma-Aminobutyric Acid Receptor

γ-氨基丁酸受体（GABA受体）是一种蛋白质， 它有助于调节大脑中神经细胞之间的通讯， 大脑和脊髓通过调节离子的运动， 神经细胞膜与控制神经兴奋性 细胞 为了了解这种受体的功能， 来了解它的三维结构。 这可以确定 用电子显微镜来了解 联合收割机形成GABA受体结构的亚基， 应该给我们更多的了解GABA受体是如何 能够调节神经元的交流。 此外，识别 GABA受体上苯二氮卓类药物与GABA结合的位点， 使用化学标记方法，将导致理解 受体在神经系统功能中的作用， 行为

The gamma-aminobutyric acid receptor (GABA receptor) is a protein which helps regulate communications between nerve cells in the brain and spinal cord by regulating the movement of ions across the nerve cell membranes and controlling excitability of nerve cells. To understand how this receptor functions it is essential to know its three-dimensional structure. This can be determined with the use of the electron microscope to learn the number of subunits which combine to form the GABA receptor structure and should give us additional insights into how the GABA receptor is able to regulate neuronal communication. Also, identifying the sites on the GABA receptor where benzodiazepines and GABA bind, using chemical labeling methods, will lead to an understanding of the function of the receptor in nervous system function and behavior.