Quantitative Morphology Tutorials and Databases for Biology

生物学定量形态学教程和数据库

• 批准号: 9121456
• 负责人: Robert Bolender
• 金额: $ 10万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 1997-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9121456&HistoricalAwards=false
• 关键词: Quantitative; Morphology; Tutorials; Databases; Biology

9121456 Bolender This project will create, using information technologies, a new infrastructure for quantitative morphology (QM) in the life sciences. It includes: (1) software for tutorials, databases, and query tools, (2) files of published data for 22 animal organs, and (3) facilities for electronic submission of data. The significance of the project is that it makes the methods and data of QM readily available to the community, organizes structural information hierarchically, and provides new research tools. The new tutorial supplies training in QM, which include morphometry, stereology, and reconstruction, through use of detailed descriptions, worked examples, calculation workscreens, simulations, and toolkits. It provides: (1) background material for biologists and computer scientists wishing to use the QM databases and (2) state-of-the-art tools for researchers interested in using these methods in the laboratory. The databases include a tutorial, data entry forms, published data and query tools. Reports allow end-users to standardize, recycle, and create new data. A new representation of QM data, called the structural phenotype, simplifies the task of searching for structural analogies and generalizations across the literature. The project actively supports the use of QM and contributes a structural component to Biomatrix. Furthermore the investigator will begin to port his work to the workstation environment. This proposal is being jointly supported by the Applications of Advanced Technology program in the Directorate for Education and Human Resources as well as the Computational Biology Activities program. *** Quantitative Morphology Tutorials and Databases for Biology

9121456该项目将利用信息技术，为生命科学中的定量形态(QM)建立一个新的基础设施。它包括：(1)教程、数据库和查询工具软件；(2)22个动物器官的已发表数据文件；(3)电子提交数据的设施。该项目的意义在于，它使质量管理的方法和数据随时可供社区使用，分层组织结构信息，并提供了新的研究工具。新的教程提供了QM方面的培训，包括形态测量、体视学和重建，通过使用详细的描述、工作示例、计算工作屏幕、模拟和工具包。它为希望使用QM数据库的生物学家和计算机科学家提供了背景材料，并为有兴趣在实验室使用这些方法的研究人员提供了最先进的工具。这些数据库包括教程、数据输入表、发布的数据和查询工具。报告允许最终用户标准化、回收和创建新数据。QM数据的一种新的表示，称为结构表型，简化了在整个文献中搜索结构类比和概括的任务。该项目积极支持QM的使用，并为Biomatrix贡献了一个结构组件。此外，调查员将开始将他的工作移植到工作站环境中。这项提议得到了教育和人力资源局的先进技术应用计划以及计算生物学活动计划的共同支持。*生物学定量形态教程和数据库