Identification of molecular drivers and protein mediators of leptomeningeal metastasis in pediatric medulloblastoma for development of novel targeted therapeutics

鉴定儿科髓母细胞瘤软脑膜转移的分子驱动因素和蛋白质介质，以开发新型靶向治疗药物

• 批准号: 416173
• 负责人: Van Ommeren Randy
• 金额: $ 10.93万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-11-01 至 2022-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=416173&lang=en
• 关键词: Bioinformatics; Cancer; Functional Genomics; Medulloblastoma; Metastasis; Molecular Biology; Neuro-Oncology; Pediatrics; Phage Display; Therapeutics

Medulloblastoma is the most common type of primary brain tumour in children and a leading cause of pediatric cancer death. Currently, affected children are treated with surgery, chemotherapy, and aggressive radiotherapy, which leaves nearly all patients w

髓母细胞瘤是儿童中最常见的原发性脑肿瘤类型，也是儿童癌症死亡的主要原因。目前，受影响的儿童通过手术，化疗和积极的放射治疗进行治疗，这使得几乎所有的患者都无法接受治疗。