The molecular mechanisms bacterial transferrin-binding proteins: towards the development of wide-range therapies

细菌转铁蛋白结合蛋白的分子机制：朝着广泛疗法的发展

• 批准号: 428947
• 负责人: Liang Yingke
• 金额: $ 1.27万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-12-01 至 2020-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=428947&lang=en
• 关键词: Bacteria Diversity; Bacterial Iron Uptake Mechanisms; Cryo-Em; Infectious Bacteria; Protein Interactions; Protein Structure; Vaccine Development; X-Ray Crystallography

"Like all organisms, dangerous pathogenic bacteria that cause diseases in humans such as meningitis and pneumonia require iron for essential biochemical reactions, which they obtain from their host by siphoning iron from iron-binding glycoproteins through

“像所有生物一样，导致人类疾病（如脑膜炎和肺炎）的危险病原菌需要铁进行基本的生化反应，它们通过从铁结合糖蛋白中吸取铁，