Cation Radicals in Solution

开发新的和综合有用的反应， 在阳离子自由基催化下进行。 的优势和 这些新的反应的属性将被调查的手段 深入研究它们的选择性特征和机制。 用于阳离子自由基的极灵敏的机械探针 参与催化反应的中间体已经被 设计，并将进一步量化和完善。 这些 探针将允许明确检测这些催化剂 一般来说，这些机制是有效的。 充分 因此，这种强大的新催化原理的范围可以是 定义了 催化机制的参与， 生物和酶模型催化的环氧化将是 使用这些探针进行检查。 自由基阳离子的参与 催化作用或与其他生物氧化作用的关系 反应也将被检查。 %%% 有了这个奖项，有机合成计划将继续 支持Nathan L博士的研究。Bauld在大学 得克萨斯州。 这项研究探索了新的分支， 阳离子自由基化学的应用。 它将 产生新的方法，应该有利于研究， 生物化学和医学以及化学工业。

The development of new and synthetically useful reactions based upon cation radical catalysis is planned. The advantages and attributes of these new reactions will be investigated by means of thorough study of their selectivity profiles and mechanisms. Extremely sensitive mechanistic probes for the cation radical intermediates involved in catalyzed reactions have been designed and will be further quantitated and perfected. These probes will permit the definitive detection of these catalytic mechanisms, in general, where these are operative. The full scope of this powerful, new catalytic principle can thus be defined. The involvement of a catalytic mechanism in biological and enzyme model catalyzed epoxidation will be examined using these probes. The involvement of radical cation catalysis in, or its relationship to other biological oxidation reactions will also be examined. %%% With this award, the Organic Synthesis Program will continue to support the research of Dr. Nathan L. Bauld at the University of Texas. The research explores new ramifications and applications of the chemistry of cation radicals. It will generate new methodology that should benefit research in biochemistry and medicine as well as in the chemical industry.