Presidential Young Investigator Award: Bioorganic Chemistry

总统青年研究员奖：生物有机化学

• 批准号: 9157486
• 负责人: Alanna Schepartz
• 金额: $ 34.5万
• 依托单位: Yale University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-01 至 1997-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9157486&HistoricalAwards=false
• 关键词: Presidential; Young; Investigator; Award; Bioorganic

Dr. Schepartz has organized her research to encompass three areas of concentration. Protein affinity cleavage will be probed by the synthesis of molecules containing a protein ligand tethered to a reactive metal ion. Current studies involve the synthesis of a synthetic peptide designed to affinity cleave the FK-506 receptor FKBP. Affinity cleaving reagents will also be developed to give entry into the realm of RNA:protein interactions. Studies on the molecular recognition of RNA will be based upon the synthesis of linked oligonucleotide probes which consist of two short DNA oligos linked by a tether of prescribed length. The sequences of the two oligos are designed to complement unique and remote single stranded regions in the RNA. Third, self-assembling molecules will be prepared utilizing the assembly of dimeric receptors using a mechanism of transition metal chelation. %%% Dr. Alanna Schepartz of the Chemistry Department at Yale University is being supported by the Synthetic Organic Program as a Preseidential Young Investigator. She will focus her research efforts in the area of macromolecular bioorganic chemistry. By combining the techniques of organic chemistry and molecular biology, Dr. Schepartz will study the molecular basis of protein recognition, molecular recognition of RNA and how to turn receptors on and off.

Schepartz博士组织了她的研究， 集中的地区。 蛋白质亲和力切割将是 通过合成含有蛋白质的分子来探测 配体与活性金属离子相连。 目前的研究 包括合成一种合成肽， 亲和切割FK-506受体FKBP。 亲和裂解 还将开发试剂，以进入 RNA：蛋白质相互作用。 分子识别研究 RNA的合成将基于 由两个短DNA寡核苷酸组成的寡核苷酸探针 用规定长度的绳子连接。 的序列 两个寡核苷酸被设计为互补独特的和远程的单个寡核苷酸， RNA中的搁浅区域。 第三，自组装分子 将利用二聚受体的组装来制备 使用过渡金属螯合机理。 %%% 耶鲁大学化学系的Alanna Schepartz博士 该大学得到了合成有机计划的支持 作为一名年轻的研究员。 她会集中精力 生物有机大分子领域的研究成果 化学. 结合有机化学的技术 和分子生物学，Schepartz博士将研究分子 蛋白质识别的基础，RNA的分子识别， 如何打开和关闭感受器