Presidential Young Investigators Award

总统青年研究员奖

• 批准号: 9158507
• 负责人: Martha Gray
• 金额: --
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-07-15 至 1997-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9158507&HistoricalAwards=false
• 关键词: Presidential; Young; Investigators; Award

The proposed research is directed to understanding the factors that govern the response of cartilage to external mechanical forces. The remodeling of cartilage, like that of bone, is a very complex response that involves a variety of chemical factors in addition to the physical forces. The PI will combine techniques of engineering, biophysics, and cellular and molecular biology to study how cells regulate tissue composition and material properties. The work will include the use of NMR spectroscopy and imaging techniques for the evaluation of the biochemical and mechanical states of cartilage. These basic bioengineering studies will result in a better understanding of the remodeling of connective tissue, and should eventually result in better diagnostic and therapeutic techniques.

该研究旨在 去理解那些 控制着软骨对 外部机械力。 的 重塑软骨，就像这样 是一种非常复杂的反应 涉及到各种化学物质 除了物理因素之外， 力. PI将联合收割机 工程技术， 生物物理学，细胞学， 分子生物学来研究 细胞调节组织成分 和材料特性。 工作 将包括使用核磁共振 光谱学和成像技术 的评价 生物化学和机械状态 软骨组织 这些基本 生物工程研究将导致 为了更好地理解 结缔组织的重塑， 并最终导致 更好的诊断和治疗 技术.