Research on Doppler Three-Dimensional Vector and Capillary Flow Measurement

这项拨款将资助超声多普勒技术的研究，以估计血流速度和检测血流相关情况。通过控制超声波换能器的孔径，将产生线状回波光谱，由此产生三维血流速度矢量，而不仅仅是沿声束轴和法向声束轴的速度分量，将被估计。通过注射到血液中的超声造影剂，也可以测量毛细血管血流和灌注。这些造影剂在入射辐射的二次谐波上比组织有更强的回声，因此毛细血管血液回声与周围组织的回声之比将得到加强。这项研究很重要，因为它可能会导致超声波技术的进步，包括电流传感器性能的改进和具有一定工作特性的传感器的设计。这项研究还可以在一些传统系统无效的地方进行流量测量。造影检查应能更有效地显示灌注程度。这些后一项研究也应该能够利用超声波对毛细管流量进行首次测量。

This grant will fund the investigation of ultrasound Doppler techniques to estimate blood velocity and detect blood flow related conditions. By manipulating the aperture of an ultrasound transducer, a line type echo spectra will be produced from which the 3-D blood velocity vector, rather than merely the velocity components along and normal to the sound beam axis, will be estimated. Capillary blood flow and perfusion also will be measured through the use of ultrasound contrast materials which can be injected into the blood. These contrast agents have a much stronger echo at the second harmonic of the incident radiation than does tissue and therefore the ratio of the capillary blood echo to that of the surrounding tissue will be enhanced. This research is important since it could lead to advances in ultrasound technology, including the improvement of the performance of current transducers and the design of transducers with certain operating features. The research also could enable flow measurements to be made in some locations where conventional systems are ineffective. The contrast studies should enable more effective visualization of the degree of perfusion. These latter studies also should enable the first measurement of capillary flow to be made using ultrasound.